Ginkgo Biloba extract formulated with phosphatidylserine for enhanced cognitive effect
In an increasingly fast-paced world, with periods of stress that often strain our mental performance, Ginkgo Biloba can be a natural support for staying focused and promoting brain health at any age.
Not coincidentally, Ginkgo Biloba is one of the most extensively studied botanical species as a natural remedy against cognitive disorders, so much so that it is revered in the East as the “memory plant,” improving cerebral circulation, strengthening capillary walls, protecting neuronal cells from oxygen depletion, and preventing clot formation.
But that’s not all. Ginkgo leaf extract is used to improve concentration and memory, enhance neuronal plasticity (which underlies learning, as it is the brain’s remarkable ability to modify its structure, function, and connections in response to stimuli), and preserve brain receptors that regulate nerve signal transmission from age-induced damage.1
Therefore, it is the plant extract, as well as a nootropic of utmost relevance to neurocognitive domains, with efficacious improvements in perceptual-motor functions as well.2
Evaluation of the evidence for each plant extract on the main neurocognitive domains.2
We selected phytosomal Ginkgo for the supplement Brain 5:5®
Phytosomal Ginkgo is an exclusive standardized dry extract of Ginkgo biloba L. leaves in a synergistic formulation with phosphatidylserine.
Because of this particular complexed form, explicitly known as “phytosome,” the plant extract not only ensures the best bioavailability and biocompatibility but also has the advantage of simultaneously delivering two active nootropic substances mutually synergistic in optimizing cognitive functions: the Ginkgo phytocomplex (rich in flavonoids and ginkgolides) and phosphatidylserine, the brain’s primary phospholipid.
Phosphatidylserine is a phospholipid component of cell membranes, occurring in high quantities in the brain, promoting critical cognitive abilities.
Rapidly absorbed because it can cross the blood-brain barrier, phosphatidylserine promotes neurotransmission efficiency by restoring acetylcholine (the primary neurotransmitter) release and inhibiting biological changes, protecting the nervous system from age-related structural deterioration.
This feature promotes cognitive functions that benefit memory and the capacity to create new memories; it enhances the ability to concentrate and use logical reasoning and fosters learning with enhanced verbal and communication skills.3
In particular, a study on healthy young subjects demonstrated that phytosomal Ginkgo, even after a single administration (6 hours), can optimize mental performance and memory. In particular, the effect of complexed Ginkgo extract in supporting working memory and its subsequent consolidation, thereby optimizing both accuracy and speed of execution, was observed.4
Combining Ginkgo with phosphatidylserine also promotes motor functions, improving reflexes and reaction time; inhibits the secretion of cortisol (a hormone released, for example, as a result of very intense exercise or following stressful situations), promoting improved sleep-wake rhythm, and a rebalancing of the hypothalamic-pituitary axis, restoring homeostasis of basal functions.4
In addition to the benefits on cognitive abilities in terms of performance, the clinical evidence of phytosomal Ginkgo in simultaneously ensuring brain well-being, an essential aspect of cognitive health over time, is, therefore, significant.4
Optimized bioavailability (thanks to the adoption of an innovative delivery system), the highest-quality plant extract, and clinically proven efficacy are all features of the select Ginkgo Biloba extract and each of the active ingredients within HAP Body Brain Skin® supplements.
More specifically, as an essential nootropic agent for brain health and function, phytosomal Ginkgo is incorporated in the exclusive, patent-pending formulation of the dietary supplement Brain 5:5® (along with Magnolia extract, nervonic acid, sialic acid, and citicoline) as a valuable ally in the challenge of Brain Healthy Aging.
Bibliography
- Singh SK, Srivastav S, Castellani RJ, Plascencia-Villa G, Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. 2019 Jul;16(3):666-674.
- Lorca, C., Mulet, M., Arévalo-Caro, C., Sanchez, M. Á., Perez, A., Perrino, M., … Serra, A. (2022). Plant-derived nootropics and human cognition: A systematic review. Critical Reviews in Food Science and Nutrition, 63(22), 5521–5545.
- Med. Rev. 2008, 13, 245-247. Progress in Lipid Research 2014, 56, 1-18.
- Stough C. et al., Int J Neuropharmacol. 4(2):131-134 (2001).