Nervonic Acid:
essential nootropic for brain physiology

Nervonic acid, present in breast milk, is a long-chain fatty acid critical for neuronal development and brain health.1

It is an essential nootropic for the growth and maintenance of brain physiology and peripheral nerve tissue.

It comprises 60% of the sphingomyelin fatty acids in the white matter of the brain, participating in the biosynthesis and maintenance of the myelin sheath of nerve cells, the alteration of which in the brain, spinal cord, and optic nerve can cause neurological deficits, such as vision problems, weakness, impaired sensitivity, and behavioral or cognitive problems.

In-vivo tests show how daily supplementation of nervonic acid promotes improved cognitive function and memory.

High serum levels of nervonic acid have also been correlated with a lower risk of developing Alzheimer’s disease, allowing nervonic acid to be associated, even though preliminarily, with a neurodegeneration-preventive action.2

In addition to promoting neuronal cell function and cognitive function through the proper conduction of nerve impulses, mechanical protection, and nutritional sustenance, nervonic acid is also an essential nutrient in terms of neuroprotection.3

It exerts anti-oxidant and anti-inflammatory action, reducing pro-inflammatory factor levels and maintaining normal cell physiology.4

Therefore, owing to its excellent bio-functions in promoting human health, nervonic acid is an excellent nutraceutical candidate for healthy aging.

the patented high-potency nootropic nervonic acid.

Our Brain 5:5® formulation contains the exclusive NutraBrain®, a patented ingredient based on Brassica Rapa dry extract titrated at 90% in nervonic acid.

In-vitro absorption studies conducted at Pavia University utilizing a dynamic system on Caco-2 corroborate NutraBrain®. The data show that our intestinal barrier can absorb 44% of the active ingredient just 4 hours after intake.

NutraBrain® is a physiological anti-oxidant adjuvant, ideal for stimulating neuronal communication and promoting brain function and memory capacities.

Learn more on the exclusive combination of Brain 5:5® 


  1. Qi Li, Jia Chen, Xiuzhu Yu, Jin-Ming Gao, A mini review of nervonic acid: Source, production, and biological functions, Food Chemistry, Vol 301, 2019, 125286, ISSN 0308-8146
  2. Liu F, Wang P, Xiong X, Zeng X, Zhang X, Wu G. A Review of Nervonic Acid Production in Plants: Prospects for the Genetic Engineering of High Nervonic Acid Cultivars Plants. Front Plant Sci. 2021 Mar 5;12:626625.
  3. Mayile Aihaiti, et al. Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D-galactose/AlCl3 in mice. Food science & nutrition vol. 11,10 5989-5998. 6 Jul. 2023, doi:10.1002/fsn3.3533
  4. Xueqi Wang, Zhengdou Li, Xu Li, Xiaoxiao Liu, YingMao, Fuliang Cao, Xinliang Zhu, Ji Zhang, Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS induced AD model mice, Biochemical Pharmacology, vol 209, 2023,115411,ISSN 0006 2952.


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