Quercetin is a natural flavonoid belonging to a group of plant compounds known as polyphenols, and it is found in many botanical species to combat environmental stresses.
In recent years, it has become one of the most studied polyphenols in aging research, so much so that it has been dubbed the “king of flavonoids” for its powerful antioxidant properties and wide range of health benefits.
In fact, from immune support to heart health and beyond, quercetin offers many benefits that satisfy diverse wellness needs.1
Quercetin’s primary benefits derive from its antioxidant properties, able to directly neutralize free radicals, activate protective enzymes, and reduce oxidative stress, but also from its ability to lower inflammation (anti-inflammatory action) and to modulate and enhance immune response (immunomodulatory action), which is increasingly lacking as a result of the aging-induced stem cell decline. 2.3
But it is also a well-known, potent natural senolytic.4,5
Senolytics are compounds able to selectively eliminate senescent cells, i.e., old cells no longer performing and functional, which, after having divided too many times or in response to DNA damage and excessive oxidative stress, lose the ability to replicate and develop programmed cell death resistance (apoptosis), preventing tissue repair and renewal resulting in the accumulation of cellular damage that fuels the aging process.
Unlike other natural senolytic compounds, however, quercetin exerts a dual and complementary action against senescent cells. In addition to promoting their elimination as a senolytic, it also exerts an anti-SASP (Senescence-Associated Secretory Phenotype) action, reducing the harmful factors produced by senescent cells.6
Indeed, senescent cells are also called “zombie cells” because, in addition to developing cell-death resistance, they remain metabolically active with a marked expression of pro-inflammatory molecules that damage neighboring cells, fueling and spreading chronic inflammation throughout the body.
So, in this way, the positive modulation of gene regulation related to the cell cycle, cell division, and proliferation, and also against genetic and epigenetic damage, combined with immunomodulatory and anti-inflammatory activity, make quercetin a key active agent in broad-spectrum counteracting the 9 Hallmarks of Aging, for healthy aging.
However, poor solubility and reduced oral absorption compromise the many beneficial potentials of this exceptional natural active ingredient, which in the traditionally used form may be unable to cross cell membranes to the bloodstream. For this reason, choosing a technologically advanced delivery formula is of primary importance in formulating a quality dietary supplement to ensure bioavailability.6
We selected a technologically advanced quercetin, delivered in phytosomal form, with the best oral bioavailability in the dietary supplement Body 9:9®.
This is pure quercetin obtained from the extraction of Sophora japonica L. flowers and complexed with natural phospholipids thanks to a patented release technology.
Compared with traditional quercetin alone, this delivery technology offers the flavonoid protection against degradation. It facilitates its effective transport through the intestinal tract, thus optimizing its bioabsorption, including independently of food intake and without the addition of synthetic adjuvants or structural modifications of the active ingredient.
In fact, a clinical study shows this innovative delivery system’s ability to achieve 20 times higher quercetin levels in the blood after oral intake than the same amount of standard quercetin, with the advantage of ensuring maximum efficacy at lower, without side effects.
Specific benefits of taking this particular form of phytosomal quercetin as a dietary supplement on the health of the body system are documented and published by the scientific literature:
Phytosomal quercetin contributes to maintaining a healthy immune system by modulating the pro-inflammatory cytokine cascade and the onset of infection symptoms, thanks to its senolytic function.
The repeated intake of a supplement containing phytosomal quercetin has been shown to reduce allergy-related symptoms (such as itchy eyes, sneezing, nasal discharge, and sleep disturbance) within 4 weeks compared to placebo, confirming the beneficial effect on immune and inflammatory processes in the upper respiratory tract, the main gateway for allergens and pathogens.
A further study confirms that, after 30 days, administration of phytosomal quercetin optimizes general well-being in allergy sufferers and modulates rhinitis, reducing the frequency of symptoms by up to 50% during the day and up to 70% at night. In addition to observing favorable eye and nose health, scientific evidence also confirms improved quality of life.
But that’s not all. Supplementation with targeted antioxidant compounds also plays a crucial role in recovery-related oxidative stress, which, if unbalanced, poses a greater risk of post-exercise pain.
Phytosomal quercetin supplementation in triathlon athletes has been shown to promote the best possible physical performance and rapid recovery after exercise in as little as 14 days. Athletes experience greater physical endurance and less discomfort related to post-ports activity, such as cramping and recovery time, balancing oxidative stress as early as 1 hour after the end of the run.
Choosing the highest quality active ingredients, such as this particular form of phytosomal quercetin, is a hallmark of HAP Body Brain Skin®, so it can offer exclusive and innovative formulations without compromise and with proven efficacy for maintaining good health over time.
All that remains is to explore Body 9:9® dietary supplement’s formulation of the highest quality synergistic ingredients to effectively include the “king of flavonoids” in your daily routine and reap its countless benefits in promoting healthy aging of the body system.
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